Dr. Zuker is a Professor at Rensselaer Polytechnic Institute (RPI) in the Department of Mathematical Sciences. Dr. Zuker works on the development and implementation of algorithms to predict nucleic acid folding and hybridization by free energy minimization using empirically derived thermodynamic parameters. Modeling and algorithm development have been closely coupled with the derivation of nearest neighbor and related energy rules. His current work is focused on the computation of partition functions for systems containing two molecules in solution that can fold as well as hybridize with each other. A related project is the development of an algorithm named FASTH that searches RNA or DNA sequence databases for optimal hybridization sites for nucleic acid query sequences. Dr. Zuker received his Ph.D. in Mathematics from the Massachusetts Institute of Technology.