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Leonard Petrucelli, PhD

Professor, Mayo Clinic College of Medicine and Science

Dr. Petrucelli is the Ralph B. and Ruth K. Abrams Professor of Neuroscience at the Mayo Clinic College of Medicine and Science in Jacksonville, Florida. His research focuses on investigating the pathological mechanisms in patients with neurodegenerative diseases including Alzheimer’s disease (AD), frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Dr. Petrucelli and his team were one of the first groups to describe both Repeat Associated Non-AUG (RAN) translation and antisense pathology in the subtype of ALS caused by repeat expansions in the C9orf72 gene and to develop a mouse model recapitulating behavioral and neuropathological features. He is also interested in TDP43 disorders and mechanisms underlying tau spread in dementia. His research focuses heavily on translation to the clinic, with efforts to identify novel therapeutic approaches to ALS, FTD and AD, as well as studies of clinically relevant biomarkers. He holds a B.S. in Biology from Barry University and a Ph.D. in Molecular and Cellular Biochemistry from Loyola University & the Stritch School of Medicine.

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