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David H. Mathews, MD, PhD

Professor, University of Rochester Medical Center

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Dr. Mathews is a Professor of Biochemistry & Biophysics at the University of Rochester Medical Center, where he oversees The Mathews Lab, which studies RNA with computational methods. The Mathews Lab is developing new methods to improve RNA secondary structure prediction, with a focus on using data from homologous sequence comparison and probing experiments, and improved methods to model the all-atom structure and dynamics of RNA. Dr. Mathews received his undergraduate degree in Physics from the University of Rochester. He also completed medical and graduate school at the University of Rochester, where he received his Ph.D. in Chemistry. Dr. Mathews’ thesis work was with Doug Turner on determining the set of free energy change nearest neighbor parameters for RNA folding, developing methods to constrain folding based on wet lab experiments, and predicting a secondary structure common to two sequences. Dr. Mathews completed a post-doc with David Case at the Scripps Research Institute, San Diego, CA, to work on all-atom modeling of RNA. Dr. Mathews has received an Alfred P. Sloan foundation fellowship and has been highlighted by Genome Technology as one of “Tomorrow’s PIs”.

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