Publications

Platform

Costales MG, Matsumoto Y, Velagapudi SP, Disney MD. Small Molecule Targeted Recruitment of a Nuclease to RNA. J Am Chem Soc. 2018;
Velagapudi SP, Gallo SM, Disney MD. Sequence-based design of bioactive small molecules that target precursor microRNAs. Nat Chem Biol. 2014;10(4):291-7.
Disney MD, Labuda LP, Paul DJ, et al. Two-dimensional combinatorial screening identifies specific aminoglycoside-RNA internal loop partners. J Am Chem Soc. 2008;130(33):11185-94.
Childs-disney JL, Wu M, Pushechnikov A, Aminova O, Disney MD. A small molecule microarray platform to select RNA internal loop-ligand interactions. ACS Chem Biol. 2007;2(11):745-54.

Small Molecule DM1 Binders

Parkesh R, Childs-disney JL, Nakamori M, et al. Design of a bioactive small molecule that targets the myotonic dystrophy type 1 RNA via an RNA motif-ligand database and chemical similarity searching. J Am Chem Soc. 2012;134(10):4731-42.
Rzuczek SG, Southern MR, Disney MD. Studying a Drug-like, RNA-Focused Small Molecule Library Identifies Compounds That Inhibit RNA Toxicity in Myotonic Dystrophy. ACS Chem Biol. 2015;10(12):2706-15.
Pushechnikov A, Lee MM, Childs-disney JL, et al. Rational design of ligands targeting triplet repeating transcripts that cause RNA dominant disease: application to myotonic muscular dystrophy type 1 and spinocerebellar ataxia type 3. J Am Chem Soc. 2009;131(28):9767-79.
Childs-disney JL, Parkesh R, Nakamori M, Thornton CA, Disney MD. Rational design of bioactive, modularly assembled aminoglycosides targeting the RNA that causes myotonic dystrophy type 1. ACS Chem Biol. 2012;7(12):1984-93.
Lee MM, Childs-disney JL, Pushechnikov A, et al. Controlling the specificity of modularly assembled small molecules for RNA via ligand module spacing: targeting the RNAs that cause myotonic muscular dystrophy. J Am Chem Soc. 2009;131(47):17464-72.
Disney MD, Lee MM, Pushechnikov A, Childs-disney JL. The role of flexibility in the rational design of modularly assembled ligands targeting the RNAs that cause the myotonic dystrophies. Chembiochem. 2010;11(3):375-82.
Childs-disney JL, Hoskins J, Rzuczek SG, Thornton CA, Disney MD. Rationally designed small molecules targeting the RNA that causes myotonic dystrophy type 1 are potently bioactive. ACS Chem Biol. 2012;7(5):856-62.
Rzuczek SG, Gao Y, Tang ZZ, Thornton CA, Kodadek T, Disney MD. Features of modularly assembled compounds that impart bioactivity against an RNA target. ACS Chem Biol. 2013;8(10):2312-21.

Chem-CLIP™ and C-Chem-CLIP™

Guan L, Disney MD. Small-molecule-mediated cleavage of RNA in living cells. Angew Chem Int Ed Engl. 2013;52(5):1462-5.
Rzuczek SG, Colgan LA, Nakai Y, et al. Precise small-molecule recognition of a toxic CUG RNA repeat expansion. Nat Chem Biol. 2017;13(2):188-193.

Chem-CLEAVE™

Guan L, Disney MD. Small-molecule-mediated cleavage of RNA in living cells. Angew Chem Int Ed Engl. 2013;52(5):1462-5.
Rzuczek SG, Colgan LA, Nakai Y, et al. Precise small-molecule recognition of a toxic CUG RNA repeat expansion. Nat Chem Biol. 2017;13(2):188-193.

Chem-CLICK™

Guan L, Disney MD. Small-molecule-mediated cleavage of RNA in living cells. Angew Chem Int Ed Engl. 2013;52(5):1462-5.
Rzuczek SG, Colgan LA, Nakai Y, et al. Precise small-molecule recognition of a toxic CUG RNA repeat expansion. Nat Chem Biol. 2017;13(2):188-193.