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“Impossible is just an opinion.” – 

Paulo Coelho

CORE VALUES

"The ridiculous to the sublime is but a step"

Mutual Respect and Support

For all the talk above about our view of you as a team member, it's important to know that more than anything we believe that whatever your contribution to Expansion, it falls flat if any fail to respect or support fellow team members.  We do not support discrimination of any sort, either during the hiring process or post hire on the basis of race, ethnicity, gender type, beliefs,.. hair style, sock wearing preferences;  It's a long list.  We seek to thrive in and through diversity and are dedicated to maintaining genuine attitudes of respect while doing our best to support and honor your uniqueness.

 

 – And while we're on it; 

WE ARE AN EQUAL OPPORTUNITY EMPLOYER. 

Accountability

We'd be remiss to mention what underlies the integrity of our work; Being accountable to one another in order to keep the integrity of our work at its highest.  We will go out of our way to ensure our goals stay in alignment with the values of Expansion Therapeutics mentioned above.   

The Silent, (absent) "I" in Team

Bring yourself to this professional outing.  "There is no "I" in Team" does resonate with appropriate equanimity  but we can't abide its limits.  If you're hired to be a part of this endeavor to cure major CNS diseases we'll need you to bring everything you have.  Stand up, say it, do it; and we'll be sure to support you in your vision same as you have come to support ours.   

Culture of Curiosity

If curios is not a state of being, we may not know what else it is.  So whatever else you may encounter as a part of the Expansion Therapeutics team, you can be sure to be both inspired and encouraged to give your curiosity a front-row seat.  Above all be sure not to keep it to yourself.  If you reverse Napoleon's logic, you'll have what we're after here:  

Read our Equal Opportunity statement  

Believe in Yourself

Scientist, Medicinal Chemistry

POSITION SUMMARY: 

ACCOUNTABILITIES & RESPONSIBILITIES:


  • Design and execute syntheses of complex organic molecules on a milligram to multi-gram scale

  • Design and synthesize molecules with druglike properties, using knowledge of SAR, ADME, PK, and in-silico and in-vitro predictors for multiparameter optimization.

  • Prepare reports and presentations for leadership and participate in internal/external meetings

  • Operate medicinal chemistry tools and techniques to plan and design synthetic targets

  • Utilize modelling software to facilitate structure-based drug design (SBDD) efforts.

  • Perform rapid and critical hit-to-lead evaluation of chemical matter identified through HTS, DEL, and fragment screens.

  • Integrate collaborative chemistry team to synthesize new analogs and probe compounds for discovery projects

  • Support the advancement of lead compounds through in-vitro and in-vivo evaluation to identify clinical development candidates.

  • Plan, coordinate, and manage research activities conducted at CROs.

  • Apply standard laboratory techniques to purify compounds with state-of-the-art techniques to characterize intermediates and final compounds


REQUIREMENTS: PROVEN EXPERIENCE, SKILLS & EDUCATION


  • Bachelors with a minimum of 5 years’ experience; or a master’s with a minimum of 2 years of experience; or a PhD with a minimum 0 - 1 yrs. related experience within synthetic organic chemistry

  • Possess strong synthetic organic chemistry expertise and apply the latest scientific methodologies to solve challenging medicinal chemistry problems.

  • Experience in advanced synthetic, purification, and spectroscopic techniques used in the preparation and characterization of complex organic molecules (HPLC, NMR, MS instrumentation) is required

  • Familiarity with standard laboratory instrumentation and software (SciFinder, Chemdraw)

  • Ability to design synthetic targets and successfully execute their syntheses

  • Proven experience with independently troubleshooting and optimizing syntheses and reactions

  • Deep understanding of the entire drug discovery R&D process, including ADME/PK, pharmacology, CMC, formulations, and computational chemistry

  • Familiarity with photo-crosslinking probe synthesis preferred

  • Ability to function as part of an interdisciplinary team in support of overall research activities and project goals


ATTRIBUTES:


  • Excellent written and oral communication skills.

  • Ability to work independently and collaborate in a multi-disciplinary environment.

  • Critical thinker with a demonstrated ability to effectively collaborate across teams and functional areas.

  • Success-oriented individual with relentless drive towards company and team goals and timelines.

  • Contribute to our company culture, sense of team and collaborative spirit.

  • Must be legally authorized to work in the United States.



Expansion Therapeutics fosters an inclusive company culture that values diverse talent, backgrounds, and experiences. We are proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, national origin, genetics, disability, age, sexual orientation, veteran status, or any other legally protected categories.

Reporting to the Senior Vice President, Drug Discovery, the candidate will be responsible for the synthesis and characterization of small molecules that bind RNA. He/She will integrate a broad understanding of synthetic organic chemistry and medicinal chemistry with the goal of developing probe molecules for a pharmacological target of interest. This is a direct laboratory position based in our Jupiter, Florida research site.


*Title will be commensurate with experience.

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LOCATIONS:

Headquarters

Boston, MA

Research

Jupiter, FL