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“Impossible is just an opinion.” – 

Paulo Coelho

CORE VALUES

"The ridiculous to the sublime is but a step"

Mutual Respect and Support

For all the talk above about our view of you as a team member, it's important to know that more than anything we believe that whatever your contribution to Expansion, it falls flat if any fail to respect or support fellow team members.  We do not support discrimination of any sort, either during the hiring process or post hire on the basis of race, ethnicity, gender type, beliefs,.. hair style, sock wearing preferences;  It's a long list.  We seek to thrive in and through diversity and are dedicated to maintaining genuine attitudes of respect while doing our best to support and honor your uniqueness.

 

 – And while we're on it; 

WE ARE AN EQUAL OPPORTUNITY EMPLOYER. 

Accountability

We'd be remiss to mention what underlies the integrity of our work; Being accountable to one another in order to keep the integrity of our work at its highest.  We will go out of our way to ensure our goals stay in alignment with the values of Expansion Therapeutics mentioned above.   

The Silent, (absent) "I" in Team

Bring yourself to this professional outing.  "There is no "I" in Team" does resonate with appropriate equanimity  but we can't abide its limits.  If you're hired to be a part of this endeavor to cure major CNS diseases we'll need you to bring everything you have.  Stand up, say it, do it; and we'll be sure to support you in your vision same as you have come to support ours.   

Culture of Curiosity

If curios is not a state of being, we may not know what else it is.  So whatever else you may encounter as a part of the Expansion Therapeutics team, you can be sure to be both inspired and encouraged to give your curiosity a front-row seat.  Above all be sure not to keep it to yourself.  If you reverse Napoleon's logic, you'll have what we're after here:  

Read our Equal Opportunity statement  

Believe in Yourself

Scientist, Computational Chemistry

POSITION SUMMARY: 

ACCOUNTABILITIES & RESPONSIBILITIES:


  • Support and assist in the development of QM/MM molecular dynamics approaches to advance our structure-based design platform.

  • Partner closely with a multidisciplinary team of medicinal chemists and structural biologists in active drug discovery programs to enhance our understanding of RNA modulator SAR.

  • Support and drive medicinal chemistry design efforts with modern computational and chemoinformatics approaches through an understanding of the SAR, ADME properties and target biology.

  • Interacting with experienced drug design team to develop novel compounds to enhance potency, selectivity, and PK properties.

  • Executing structure-based drug design for lead generation and lead optimization.

  • Creating pharmacophore, homology, QSAR and other empirical models.

  • Accessing and manipulating sequence, crystallographic data, and homology modeling.

  • Champion emerging opportunities in ligand-based (pharmacophore modeling, shape-based expansion) and structure-based design (homology modeling, virtual screening).

  • Develop hypotheses of the mechanism of action and binding modes of lead compounds based on a deep understanding of current structural biology and homology models.


REQUIREMENTS: Proven Experience, Skills and Education:


  • PhD in computational chemistry.

  • Minimum of 2 years relevant industrial research experience and/or post doctorial experience.

  • Extensive experience in the use of molecular dynamics in the study of ligand / target interactions.

  • Practical working experience in computational chemistry software e.g., Schrodinger, Moe, OpenEye etc.

  • Passion for the application and development of MD methods in drug design and enjoy working in a fast-paced multidisciplinary team environment at the frontier of a new paradigm in drug discovery.

  • Deep knowledge in the use of QM/MM mixed methods preferred.

  • Relevant experience studying RNA molecular dynamics, a plus.

  • Proficiency in a widely used programming/scripting language (e.g., Python /Java) a plus.


ATTRIBUTES:


  • Excellent written and oral communication skills.

  • Ability to work independently and collaborate in a multi-disciplinary environment.

  • Critical thinker with a demonstrated ability to effectively collaborate across teams and functional areas.

  • Success-oriented individual with relentless drive towards company and team goals and timelines.

  • Contribute to our company culture, sense of team and collaborative spirit.

  • Must be legally authorized to work in the United States.


Expansion Therapeutics fosters an inclusive company culture that values diverse talent, backgrounds, and experiences. We are proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, national origin, genetics, disability, age, sexual orientation, veteran status, or any other legally protected categories.

Reporting to the Vice President, Computational Chemistry, the candidate will play a key role in the ongoing development of Expansion’s RNA structure-based design platform and drug discovery endeavors. Central to this will be the advancement of our understanding of RNA binder molecular dynamics and SAR using state of the art computational chemistry software. A key aspect of this position is teamwork and the ability to collaborate with chemists, structural biologists, and the assay group to create and maintain a cohesive strategy to drive both platform development and our medicinal chemistry efforts.


*Title will be commensurate with experience.

Jan 19, 2023

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