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“Impossible is just an opinion.” – 

Paulo Coelho

CORE VALUES

"The ridiculous to the sublime is but a step"

Mutual Respect and Support

For all the talk above about our view of you as a team member, it's important to know that more than anything we believe that whatever your contribution to Expansion, it falls flat if any fail to respect or support fellow team members.  We do not support discrimination of any sort, either during the hiring process or post hire on the basis of race, ethnicity, gender type, beliefs,.. hair style, sock wearing preferences;  It's a long list.  We seek to thrive in and through diversity and are dedicated to maintaining genuine attitudes of respect while doing our best to support and honor your uniqueness.

 

 – And while we're on it; 

WE ARE AN EQUAL OPPORTUNITY EMPLOYER. 

Accountability

We'd be remiss to mention what underlies the integrity of our work; Being accountable to one another in order to keep the integrity of our work at its highest.  We will go out of our way to ensure our goals stay in alignment with the values of Expansion Therapeutics mentioned above.   

The Silent, (absent) "I" in Team

Bring yourself to this professional outing.  "There is no "I" in Team" does resonate with appropriate equanimity  but we can't abide its limits.  If you're hired to be a part of this endeavor to cure major CNS diseases we'll need you to bring everything you have.  Stand up, say it, do it; and we'll be sure to support you in your vision same as you have come to support ours.   

Culture of Curiosity

If curios is not a state of being, we may not know what else it is.  So whatever else you may encounter as a part of the Expansion Therapeutics team, you can be sure to be both inspired and encouraged to give your curiosity a front-row seat.  Above all be sure not to keep it to yourself.  If you reverse Napoleon's logic, you'll have what we're after here:  

Read our Equal Opportunity statement  

Believe in Yourself

Scientist, Biophysics

POSITION SUMMARY: 


ACCOUNTABILITIES & RESPONSIBILITIES:


  • Develop, drive and track towards key priorities for biophysics studies across multiple programs

  • Design and implement biophysical characterization of RNA-ligand and RNA-protein interactions using an array of biophysical techniques such as BLI, SPR, etc.

  • Investigate binding kinetics and characteristics in vitro and in cellular models

  • Partner and build strong relationships with team members in structural biology, biochemistry and chemistry to build robust screening paradigms and drive SAR, in order to advance hit-to-lead and lead optimization activities.

  • Drive deep mechanistic understanding of ligand binding and collaborate with colleagues to integrate this into pharmacology studies, both in vitro and in vivo

  • Interpret study results and develop further recommendations for each program

  • Independently communicate results in the form of oral presentations and industry-standard study reports

  • Prepare reports and presentations for leadership and participate in internal/external meetings

  • Make intellectual contributions to all aspects of hit finding and lead discovery


REQUIREMENTS: Proven Experience, Skills and Education:


  • PhD in biophysics, biochemistry, or a related scientific field.

  • Minimum 5 years of industry experience, preferably in the field of RNA biology.

  • Experience developing, running, and interpreting biophysical characterizations of small molecules in an industrial setting is essential; hands on experience is required

  • Familiarity with key concepts and computational tools related to RNA structure, repeat expansion, alternative splicing, translation, or other areas of RNA biology is strongly preferred.

  • Ability to function in a scientific expert role as part of an interdisciplinary team, contributing to the execution of experiments in support of overall research activities and project goals.


ATTRIBUTES:


  • Excellent written and oral communication skills.

  • Ability to work independently and collaborate in a multi-disciplinary environment.

  • Critical thinker with a demonstrated ability to effectively collaborate across teams.

  • Success-oriented individual with relentless drive towards company and team goals and timelines.

  • Contribute to our company culture, sense of team and collaborative spirit.

  • Must be legally authorized to work in the United States.


Expansion Therapeutics fosters an inclusive company culture that values diverse talent, backgrounds, and experiences. We are proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, national origin, genetics, disability, age, sexual orientation, veteran status, or any other legally protected categories.

Reporting to the Senior Vice President, Research, the Scientist, Biophysics will be key member of our Research group, responsible for the biophysical and mechanistic characterization of small molecules binding to RNA. The Principal Scientist will integrate a broad understanding of biophysics with RNA dynamics, enzymology, and structural biology with the goal of understanding the molecular mechanism of action and corresponding pharmacology of a diverse set of RNA targets. Industry experience in biophysical biology is essential. This is a hands-on laboratory position based in our Jupiter, Florida research site.


*Title will be commensurate with experience.

Sep 20, 2021

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LOCATIONS:

Headquarters

Boston, MA

Research

Jupiter, FL