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“Impossible is just an opinion.” – 

Paulo Coelho


"The ridiculous to the sublime is but a step"

Mutual Respect and Support

For all the talk above about our view of you as a team member, it's important to know that more than anything we believe that whatever your contribution to Expansion, it falls flat if any fail to respect or support fellow team members.  We do not support discrimination of any sort, either during the hiring process or post hire on the basis of race, ethnicity, gender type, beliefs,.. hair style, sock wearing preferences;  It's a long list.  We seek to thrive in and through diversity and are dedicated to maintaining genuine attitudes of respect while doing our best to support and honor your uniqueness.


 – And while we're on it; 



We'd be remiss to mention what underlies the integrity of our work; Being accountable to one another in order to keep the integrity of our work at its highest.  We will go out of our way to ensure our goals stay in alignment with the values of Expansion Therapeutics mentioned above.   

The Silent, (absent) "I" in Team

Bring yourself to this professional outing.  "There is no "I" in Team" does resonate with appropriate equanimity  but we can't abide its limits.  If you're hired to be a part of this endeavor to cure major CNS diseases we'll need you to bring everything you have.  Stand up, say it, do it; and we'll be sure to support you in your vision same as you have come to support ours.   

Culture of Curiosity

If curios is not a state of being, we may not know what else it is.  So whatever else you may encounter as a part of the Expansion Therapeutics team, you can be sure to be both inspired and encouraged to give your curiosity a front-row seat.  Above all be sure not to keep it to yourself.  If you reverse Napoleon's logic, you'll have what we're after here:  

Read our Equal Opportunity statement  

Believe in Yourself

Associate Director / Director Medicinal Chemistry



  • Drive state-of-the-art multi-parameter medicinal chemistry optimization with creativity, innovation, and in-depth analysis of data

  • Implement strategies, manage research efforts within the project teams, and coordinate efforts with contributing platform groups

  • Contribute to compound design and synthetic route identification in an impactful manner

  • Ensure project progression by prioritizing critical path activities in medicinal chemistry

  • Drive and facilitate project team productivity, execution with a sense of urgency, teamwork, accountability, high scientific rigor, and excellence

  • Manage external chemistry teams at CROs with clear, open, and direct communication to ensure a high-level productivity

  • Partner and build strong relationships across the R&D organization to work collaboratively and efficiently across functions to achieve company goals

  • Function as an impactful contributor and leader of project teams, as well as transverse and cross-functional initiatives

  • Communicate effectively to provide medicinal chemistry strategies, updates, and novel ideas in meetings with colleagues and partners; encouraging curiosity and challenging the status quo in order to foster innovative drug discovery

  • Maintain scientific and technical expertise through familiarity with scientific literature and attending conferences

  • Perform all duties in keeping with the Company’s core values, policies and all applicable regulations


  • PhD in organic chemistry with a minimum of 10-12 years of industry experience

  • Demonstrated leadership in medicinal chemistry and drug discovery with a strong record of scientific innovation, and delivery of clinical candidates

  • Experience implementing medicinal chemistry strategies across all stages of drug discovery from hit to lead and lead optimization to candidate selection

  • Experience working as part of multi-disciplinary drug discovery teams and adept at using diverse data from biology, DMPK, biochemistry and pharmacology to drive medicinal chemistry strategies

  • Experience managing and prioritizing activities of external chemistry teams at a CRO

  • Excellent synthetic chemistry skills and creativity are required

  • Experience using tools for cheminformatics, structure-based, and computer-aided design

  • Appreciation of the entire drug discovery R&D process, including ADME/PK, pharmacology, CMC, and formulation

  • Demonstrated ability in working with highly skilled teams in a fast-paced, entrepreneurial, and technical environment.


  • Excellent written and oral communication skills.

  • Ability to work independently and collaborate in a multi-disciplinary environment.

  • Critical thinker with a demonstrated ability to effectively collaborate across teams.

  • Success-oriented individual with relentless drive towards company and team goals and timelines.

  • Contribute to our company culture, sense of team and collaborative spirit.

  • Must be legally authorized to work in the United States.

Expansion Therapeutics fosters an inclusive company culture that values diverse talent, backgrounds, and experiences. We are proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, national origin, genetics, disability, age, sexual orientation, veteran status, or any other legally protected categories.

Reporting to the Senior Vice President, Research, the Associate Director / Director in Medicinal Chemistry will be a key member of our Drug Discovery and Research teams tasked with devising and driving medicinal chemistry strategies across novel drug discovery projects with the goal of advancing through hit-to-lead and lead optimization studies to clinical candidate selection. The successful  candidate will have a proven track record of success in medicinal chemistry with accomplishments resulting in high impact on drug discovery programs and/or delivery of high-quality development candidates. The candidate will work collaboratively within an energetic, matrixed research organization, helping guide teams and communicate the importance of our work to a broad audience. This position will be based in Boston/Cambridge, MA.

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Boston, MA


Jupiter, FL