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Job Type: Research

Posting date:  October  21, 2021

Senior Scientist

POSITION SUMMARY: 

Reporting to the Vice President of Computational chemistry, You will play a key role in the ongoing development of Expansions’s RNA structure-based design platform and drug discovery endeavors. Central to this will be the advancement of our understanding of RNA binder molecular dynamics and SAR using state of the art computational chemistry software. A key aspect of this position is teamwork and the ability to collaborate with chemists, structural biologists, and the assay group to create and maintain a cohesive strategy to drive both platform development and our medicinal chemistry efforts.  Title will be commensurate with experience.

DUTIES & RESPONSIBILITIES:

The successful candidate will:

  • Play a central role in the ongoing development of QM/MM molecular dynamics approaches to advance our structure-based design platform.

  • Work closely with a multidisciplinary team of medicinal chemists and structural biologists in active drug discovery programs to enhance our understanding of RNA modulator SAR.

  • Have a passion for the application and development of MD methods in drug design and enjoy working in a fast-paced multidisciplinary team environment at the frontier of a new paradigm in drug discovery.

Computational Chemistry

EDUCATION/EXPERIENCE

  • PhD in computational chemistry.

  • A minimum of 2 years relevant industrial research experience and/or post doctorial experience.

  • Extensive experience in the use of molecular dynamics in the study of ligand / target interactions.

  • Practical working experience in computational chemistry software e.g. Schrodinger, Moe, OpenEye etc.

  • Experience in the use of QM/MM mixed methods preferred.

  • Experience studying RNA molecular dynamics a plus.

  • Expertise in a widely used programming/scripting language (e.g. Python / Java)  a plus.

Expansion Therapeutics fosters an inclusive company culture that values diverse talent, backgrounds, and experiences. We are proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, national origin, genetics, disability, age, sexual orientation, veteran status, or any other legally protected categories.

ATTRIBUTES

  • Excellent written and oral communication skills.   

  • Ability to work independently and collaborate in a multi-disciplinary environment.

  • Critical thinker with a demonstrated ability to effectively collaborate across teams and functional areas.

  • Success-oriented individual with relentless drive towards company and team goals and timelines.

  • Contribute to our company culture, sense of team and collaborative spirit.

  • Must be legally authorized to work in the United States.

LOCATION

This position can be remote or on site at our labs in Jupiter Fl depending on candidate preference.

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LOCATIONS:

Headquarters

Boston, MA

Research

Jupiter, FL