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Job Type: Discovery

Posting date:  September  20, 2021

Director, Medicinal Chemistry


Reporting to the Senior Vice president of Drug Discovery, the Director of Medicinal Chemistry will be a key member of our research group, responsible for developing and driving medicinal chemistry strategies across novel drug discovery projects with the goal of advancing through hit-to-lead and lead optimization studies to clinical candidate selection.

The successful candidate will have a proven track record of success in medicinal chemistry with accomplishments resulting in high impact on drug discovery programs and/or delivery of high-quality development candidates. This position will be based in Boston/Cambridge, MA.


  • Lead, develop, and implement medicinal chemistry strategies to discover novel therapeutics providing subject matter expertise in the field of medicinal chemistry and related disciplines (e.g., drug metabolism, biology, computational chemistry, process chemistry)

  • Design and prioritize medicinal chemistry plans to deliver small molecule development candidates

  • Lead multi-disciplinary drug discovery and development teams to IND Stage

  • Build, maintain, and grow strong productive relationships with internal and external colleagues in chemistry, structural biology, ADME, biology and pharmacology

  • Establish the intellectual property strategy working with internal and external patent counsel and lead the preparation of patent documents, peer reviewed scientific publications and regulatory documents, as appropriate

  • Drive state-of-the-art multi-parameter medicinal chemistry optimization with creativity, innovation, and in-depth analysis of data

  • Communicate effectively to provide project updates, medicinal chemistry strategies and novel ideas in meetings with colleagues and partners

  • Ensure project progression by prioritizing critical path activities in medicinal chemistry 

  • Manage outsourced chemistry teams at CROs with clear, open, and direct communication to ensure a high-level productivity

  • As part of a multidisciplinary team, work collaboratively and effectively across functions to achieve company goals

  • Perform all duties in keeping with the Company’s core values, policies and all applicable regulations


  • PhD in organic chemistry with >10 years with a strong record of scientific innovation, and delivery of clinical candidates

  • Demonstrated leadership in medicinal chemistry and drug discovery and a track record of success-based performance and accomplishment

  • Understanding of the entire drug discovery R&D process, including ADME/PK, pharmacology, CMC, formulations, and computational chemistry

  • Deep expertise implementing medicinal chemistry strategies across all stages of drug discovery from hit to lead and lead optimization to candidate selection

  • Proven accomplishments in Drug Discovery that have led to delivery of clinical candidates

  • Extensive knowledge in the use of cheminformatics, structure-based, and computer-aided design tools

  • Well-developed synthetic chemistry skills and creativity are required

  • Experience managing external chemistry teams 


  • Ability to thrive in a fast-paced, dynamic small company environment 

  • Critical thinker with a demonstrated ability to effectively collaborate across teams and functional areas

  • Capacity to synthesize and integrate complex ideas and to clearly communicate key insights around our targets, mechanisms, and models

  • Skilled at identifying and solving problems early; forward thinking to minimize program risk

  • Success-oriented individual with relentless drive towards company and team goals and timelines

  • Curiosity, passion, and desire to make a difference

  • Contribute to our company culture, sense of team and collaborative spirit

Expansion Therapeutics fosters an inclusive company culture that values diverse talent, backgrounds, and experiences. We are proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, national origin, genetics, disability, age, sexual orientation, veteran status, or any other legally protected categories

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