• LinkedIn
  • Twitter

Site Under Construction

Open Site Navigation

Job Type: Research

Posting date:  September  20, 2021

Principal Scientist, Biophysics


The Principal Scientist, Biophysics will be key member of our Research group, responsible for the biophysical and mechanistic characterization of small molecules binding to RNA. The Principal Scientist will integrate a broad understanding of biophysics with RNA dynamics, enzymology and structural biology with the goal of understanding the molecular mechanism of action and corresponding pharmacology of a diverse set of RNA targets.  Industry experience in biophysical biology is essential. This is a hands-on laboratory position based in our Jupiter, Florida research site.


Essential duties and responsibilities include the following.  

  • Establish and track towards key priorities for biophysics studies across multiple programs

  • Design and implement biophysical characterization of RNA-ligand and RNA-protein interactions using an array of biophysical techniques such as BLI, SPR, etc

  • Investigate binding kinetics and characteristics in vitro and in cellular models

  • Close collaboration with team members in structural biology, biochemistry and chemistry to build robust screening paradigms and drive SAR, in order to advance hit-to-lead and lead optimization activities.

  • Drive deep mechanistic understanding of ligand binding and collaborate with colleagues to integrate this into pharmacology studies, both in vitro and in vivo

  • Interpret study results and develop further recommendations for each program

  • Independently communicate results in the form of oral presentations and industry-standard study reports 

  • Prepare reports and presentations for leadership and participate in internal/external meetings

  • Make intellectual contributions to all aspects of hit finding and lead discovery

  • Perform all duties in keeping with the Company’s core values, policies and all applicable regulations

  • Perform all duties in keeping with the Company’s core values, policies and all applicable regulations.


Minimum Requirements:

PhD in biophysics, biochemistry, or a related field. 

At least 5 years of industry experience, preferably in the field of RNA biology.

Experience developing, running and interpreting biophysical characterizations of small molecules in an industrial setting is essential; hands on experience is required

Familiarity with key concepts and computational tools related to RNA structure, repeat expansion, alternative splicing, translation or other areas of RNA biology is strongly preferred.

Ability to function in a scientific expert role as part of an interdisciplinary team, contributing to the execution of experiments in support of overall research activities and project goals.



Ability to thrive in a fast-paced, dynamic small company environment 

Critical thinker with a demonstrated ability to effectively collaborate across teams and functional areas

Capacity to synthesize and integrate complex ideas and to clearly communicate key insights around our targets, mechanisms and models.

Skilled at identifying and solving problems early; planning ahead to minimize program risk.

Success-oriented individual with relentless drive towards company and team goals and timelines.

Curiosity, passion and desire to make a difference

Contribute to our company culture, sense of team and collaborative spirit.

Expansion Therapeutics fosters an inclusive company culture that values diverse talent, backgrounds, and experiences. We are proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, national origin, genetics, disability, age, sexual orientation, veteran status, or any other legally protected categories.

© 2021 Expansion Therapeutics     |    Terms of Use    |    Privacy Policy    |    info@expansionrx.com



Boston, MA


Jupiter, FL